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While some individuals may begin to feel a difference in their symptoms, such as reduced discomfort from an injury, within a few weeks, the more profound and sustained benefits typically become apparent after a few weeks to a few months of consistent therapy

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31 Predicting drug elimination based on half-life can go awry when very high doses of drugs are used, 32 as in the case of fluoxetine and the treatment of obsessive-compulsive disorder and when drugs are consumed in overdose